Mapping Mechanistic Pathways of Acute Oral Systemic Toxicity Using Chemical Structure and Bioactivity Measurements

Regulatory agencies around the world have committed to reducing or eliminating animal testing for establishing chemical safety.Adverse outcome pathways can facilitate replacement by providing a mechanistic framework for identifying the appropriate non-animal methods and connecting them to apical adverse outcomes.This study separated 11,992 chemical

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INFLUENCE MASS OF THE RINGS, RESILIENTLY SET ON DISK, ON DYNAMIC DESCRIPTIONS OF HYDROSTATODYNAMIC BEARING OF THE DOUBLED TYPE

The task is to develop recommendations for the design of dual-type hydrostatodynamic plain bearings based on the existing experience in designing this type of plain bearings, as well as based on many theoretical and experimental studies performed by the author of this work.The number of the most necessary parameters for the design read more of dual

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Identification of C3 and FN1 as potential biomarkers associated with progression and prognosis for clear cell renal cell carcinoma

Abstract Background Clear cell renal cell carcinoma (ccRCC) is one of the most lethal urological malignancies, but the pathogenesis and prognosis of ccRCC remain obscure, which need to be better understand.Methods Differentially expressed genes were identified and function enrichment analyses were performed using three publicly available ccRCC gene

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